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Interestingly, no counter response action of the energy-deprived mutants' levels of central intermediates and metabolic genes was observed.

It follows that in igu mutants, levels of the Gli-R forms will be significantly reduced, leading to an increase in the relative levels of Gli-A forms.

Note that in these At1g71720 insertion mutants, levels of LSU were not reduced as dramatically as in the rlsb-silenced plants (approximately 5-fold, as opposed to 25 50 fold in the rlsb-silenced plants).

We could not discover the cause for this catch-up, but it was associated with normalization of T3 and IGF1 levels such that in the adult mutants, levels of these hormones were normal.

In six mutants, levels of only a few transcripts were significantly altered in either direction, whereas in the control mutant hcf145, only the psaA psaB rps14 transcript showed a marked decrease (Supplementary Table S2).

When autophagy is blocked at the step of autophagosome formation such as in epg-3, -4, and -6 mutants, or at the maturation step such as in epg-5 mutants, levels of both LGG-1-I and LGG-1-II are elevated compared to wild-type animals (Fig. 2A ).

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Similar(52)

For the K270R mutant, levels of IFN-β activation elicited by the 14-mer are comparable to those observed for the 10-mer; however, this mutant also exhibited no signaling when challenged by either the 30- or 50-mer hairpins.

In this mutant, levels of mature and pre-tRNAs were unchanged, indicating that the observed effects of Nrd1 and Nab3 on tRNAs are independent of their association with Pol II.

Under similar conditions, the larger isoform hTid-1L stimulated wild-type to 6-fold when compared with the mutant levels of 8.5-fold (R126W) and 13-fold (P509S), respectively (P < 0.05, Fig.  1C).

For the A293E and A293I mutants the levels of agonist-independent phosphorylation were 150% and 50% higher than those of the wild-type alpha-1b AR, respectively.

In dimm mutants, the levels of secretory neuropeptides in the central nervous system are diminished.

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