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With these mutants it demonstrated that the depletion of inositol is essential for the prophylactic effect of Li.
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Using thermosensitive yeast mutants, it is demonstrated that both TcOrc1/Cdc6 and TbOrc1/Cdc6 can complement the cdc6 mutant, but not the orc1 mutant [ 119].
By expressing PqsE in AQ-negative pqsA or pqsR mutants, it was demonstrated that pyocyanin, rhamnolipid and elastase production could be restored in the absence of AQs.
These findings are consistent with the initial report on the characterization of these mutant mice, in which it demonstrated this mouse line undergoes normal development [12].
Aphid vector transmissibility was nearly or completely eliminated in the case of four of the mutants; two mutants demonstrated intermediate aphid transmissibility.
Based on the analysis of cutin biosynthesis mutants, it has been demonstrated that plant cuticle is required for the regulation of ABA biosynthesis and osmotic stress tolerance.
In transgenic mice overexpressing some of the ALS-associated PTC mutants, it has been demonstrated that an N-terminal SOD1 polypeptide of 125 amino acid has sufficient ALS-associated toxicity (5, 13– 13).
In vitro study on one of the "hot-spot" mutants has demonstrated it as an activating mutation.
Although genome stability appears to be compromised [ i.e., increased spontaneous chromosome loss and break-induced repair (BIR)] in adaptation-proficient mutants, it has also been demonstrated that adaptation results in cells with higher resistance upon exposure to DNA-damaging agents (e.g., X irradiation) in diploid cells (Galgoczy and Toczyski 2001).
In addition, we have applied the Amplifluor® genotyping to the mapping of C. elegans mutants and demonstrated that it is possible to link a C. elegans mutation to 5 8 Mb sub-chromosomal regions using only 9 SNPs.
In one mutant it could be demonstrated that the wild-type allele was also expressed, providing evidence that secondary mutations had occurred.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com