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The clinical relevance of Q136K mutants is unknown.
Tor1, Sch9 and Ras2 are important regulators of aging, however, whether actin dynamics is required for longevity of tor1Δ, sch9Δ, and ras2Δ mutants is unknown.
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Most studies of Tau propagation have used mutant forms, although a majority of tauopathies are sporadic and involve only the WT species and whether WT human Tau spreads as readily as the FTDP-17 Tau mutant is unknown.
However, stability of the two transposon mutant variants is unknown since a Western blot signal could not be observed using the F. novicida Hfq specific antisera (data not shown).
The background of the original bl mutant strain is unknown (40).
Although events associated with non-apoptotic cell death pathways such as poly-ADP-ribose-polymerase and calpain activation occur in rods dying due to elevated cGMP, the molecular cascade activated in degenerating Pde6 mutant photoreceptors is unknown.
Whether the differences in placental morphogenesis and/or maternofetal nutrient exchange between mouse and human contributes to the placental mineralization observed in Sucla2 mutant placenta is unknown and requires further investigation.
The reason for the discrepancy in allele frequency between GSH1 and the other five mutations from UV mutant population sequencing is unknown but may be a population sequencing artefact.
This drug, vemurafenib PLX-40322), selectargetstargets V600E mutant BRAF and it is unknown how this drug may affect autophagic flux.
Although its specific role in L. maculans is unknown, LopB- mutants showed impaired ability to form lesions on oilseed rape [ 35].
To our knowledge, transmission electron microscopy has not yet been performed on MKS3 mutant renal cilia, so it is unknown whether renal cilia have perturbations in microtubule doublet number or arrangement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com