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One way to overcome these resistant mutants is to design new ATP-competitive inhibitors, as demonstrated by the second-generation Bcr Abl inhibitors nilotinib and dasatinib.
Another assay to test the activity of the Ser103 mutants is to investigate whether these mutants affect the dominant BicD phenotype.
One of the fundamental steps in linking evolutionarily variable phenotypes to phenotypes of genetic mutants is to express both kinds of phenotypes using the same formalism.
An important consideration in screening for memory mutants is to determine if mutations disrupt performance (including perception, motivation, and motoric processes) rather than actual memory.
One of the main reasons for sequencing mutants is to account for clonal expansion [ 3].
An important advantage of the TRKO mutants is to identify genes that are common to specific biological processes.
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And, of course, there's Washington DC, where the mutants are to encounter the president, Richard Nixon (Mark Camacho), in a truly spectacular setting.
The quickest way to generate a mutant is to order it from a stock center.
The ability to evolve robust mutants is known to depend on the network architecture.
Polydactyly in Dkk1 mutants is due to an interaction with Wnt7a, which regulates digit number (Adamska et al., 2004).
In the other approach, Met to Gln mutants were designed to mimic site-specific Met oxidation.
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