Sentence examples for mutants is mediated from inspiring English sources
Intriguingly, recent observations showed that fragile site expression in mec1 mutants is mediated by condensins and DNA topoisomerase II (Hashash et al., 2012).
Therefore, we investigated whether the protection from heat stress in ppk29 mutants is mediated by the loss of PPK29 channel activity or the up-regulation of sei mRNAs (As shown in Figure 3E,F).
This finding suggests that the proteolysis of most unstable ts mutants is mediated by the proteasome, whereas a few other mutants are degraded by a different pathway in the cell (e.g. macro-autophagy).
The predominance of enriched motifs in up-regulated gene sets suggests that the life span extension of these mutants is mediated by activation rather than repression of some transcription factors.
To ascertain whether the telomere elongation phenotype of pot-1 and pot-2 mutants is mediated by telomerase, we crossed the pot-1 and pot-2 mutations into a telomerase-deficient background by constructing double and triple mutants with a null allele of the telomerase reverse transcriptase, trt-1 (ok410 ).
Much evidence shows that the longevity prolonging effects of IIS mutants are mediated by the FOXO transcription factor, DAF-16 [ 2, 52, 53].
Thus, it is likely that that the increase in protease production in the imeBΔ mutant is mediated by XprG.
We postulated that the degradation of the Pro3-1 mutant is mediated by a proteasome-dependent QC pathway.
10.7554/eLife.01498.022 Figure 7. Aberrant phenotype of the PLM neuron in the ptrn-1 mutant is mediated partially by the DLK-1 pathway.
We suggest that upregulation of ISA1 and other genes in the GM077 mutant is mediated by the SUSIBA2-like transcription factor.
Interestingly, despite retaining lysine 402, mutation of the SUMOylation consensus site in the 3mutCS mutant reduced SUMOylation of Ago2 more profoundly than mutation of K402 to arginine, strongly suggesting that the residual SUMOylation of the K402R mutant is mediated through recruitment of Ubc9 via the consensus sequence surrounding K402 (Fig. 3B).
