Cyp2c70, downregulated in the liver of Dll1 mutants, is involved in linolenic and arachidonic acid metabolism.
Consistent with this, a high proportion of deregulated transcripts in esl1 Δ esl2 Δ mutants is involved in hexose transport, lactose transport, and carbohydrate metabolism (e.g., HXT13, HXT3, HXT6, HXT7, JEN1, HXK1, PGM2, MAL12, MAL32, and MAL33 ; Table 1), and should have been repressed under the high glucose conditions during the experiment.
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Additional genes involved in such synthetic interactions with ORC mutants are involved in cohesion [20].
The observation that numerous TS lethal, and not other TS mutants, are involved in protein synthesis, transport, or, as suggested by the current study, protein quality control (Table 4), implies that additional TS lethal mutants generated by Inoue and colleagues in Neurospora [4] may impact protein synthesis pathways.
Increased genes shared by Nes-Cre- and Pax8+/Cre-driven mutants were involved in the negative regulation of cell death, response to hypoxia and positive regulation of cell migration.
This set of mpk4 associated factors indicates that the mutant is involved in responses to both virulent and avirulent pathogens, and that the mutant has an expression profile like that of wild type plants treated with the hormone salicylic acid.
In conclusion, osarf16, an auxin insensitive mutant, was involved in iron deficiency response in rice.
Microarray analysis showed that a large proportion of down-regulated genes in the abl1 mutant are involved in stress responses.
In order to narrow down which amino acid residues of the PfPdx1 DKK triple mutant are involved in PfPdx1 PfPdx1 interactions, the three amino acids were mutated individually and the derived proteins were analysed by SLS.
It also suggested that the protonation of H18 and/or of H94, the only two remaining histidine residues in the double mutant, was involved in the neutral mid-point.
