Sentence examples for mutants is difficult from inspiring English sources

We also note that the finding that BRM and SYD binding to FIL and LFY promoters is lost in mp mutants is difficult to interpret due to the dramatic mp phenotypes and the resulting cellular reprogramming effects.

The reason for the arbutin resistance of the 4 other mutants is difficult to explain and is probably not related to OPGs suggesting that arbutin affects several different cellular processes.

4) The argument in the Discussion section explaining the lack of localization of NF1-WT in axeB mutants is difficult to understand as there is no evidence that over-expression of active NF1 leads to loss of macropinosomes.

Direct correlation of clinical severity with the activity of HDAC8 mutants is difficult, because of the X-linked nature of the HDAC8 gene, which results in the random inactivation of this gene in various tissues in females.

Small-scale chemical mutagenesis screens have been performed in Tribolium [ 12, 13], but stock-keeping of unmarked recessive mutants is difficult due to the number of chromosomes (n = 10) and the lack of balancers (< 50% of the genome is covered) [ 14].

In addition, we have encountered that many A. niger mutants are difficult to transform if genomic integration has been approached (e.g. ΔhacA, data not shown).

However, similar experiments with condensin mutants are difficult to interpret as condensin is critical for chromosome arm segregation in anaphase (Renshaw et al., Dev Cell 2010).

Tip cells in homozygous mutants were difficult to identify by visual inspection, as only few filopodia extended from vessel termini, where tip cells normally reside.

Completely S-layer-negative Lactobacillus mutants are difficult or impossible to create (Palva et al. unpublished data; Boot et al. 1996a; Martinez et al. 2000; Buck et al. 2005), indicating that at least one functional S-layer protein gene is essential for S-layered lactobacilli, and expression of S-layer protein genes thus could be anticipated to be constitutive.

Previous observations on decreased Lbx1 expression in Pax3 mutants were difficult to interpret because of cell death in the hypaxial somite, where the gene is expressed at limb levels [ 1], however the gain of function result shown here indicates that Pax3 lies genetically upstream of Lbx1.

Again, the W293 mutant was difficult to express, and did not cause relocalization to theER/perinuclear region (results not shown).