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In addition, these two mutants induce a constitutive β-arrestin recruitment.
Increasing concentrations of glucose on different auxin perception tir1 and signaling slr1/iaa14, axr3/iaa17 and axr2/iaa7 mutants induce a differential response in terms of root growth and lateral roots induction.
LRRK2 expression has been shown to regulate neuronal morphology in vitro where familial LRRK2 mutants induce a reduction of neurite length and branching, and LRRK2 deficiency produces opposing effects [20].
While all 4 mutants induce a typical LT+ phenotype, RISP disruption additionally leads to an unusually perinuclear concentration of LysoTracker punctae, which was replicated by expression of RNAi against RISP (Fig. 4G).
The helicase-dead mutants induce a delay in S-phase progression and show enhanced lethality in combination with genes involved in DNA repair, suggesting that the helicase activity impedes the proper processing of the appropriate DNA repair pathway [37].
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These results demonstrate that VSV mutants induce an antitumor immune response using several mechanisms.
Despite the fact that wild-type and G mutants induced a stronger gp33-specific immune response compared to the MM51R mutant, all VSV strains showed a similar capacity to slow down tumor progression.
All mutations changed the way the protein interacted with the lipid membrane, and selected mutants induced a variety of conformational changes in both p110α and its interaction p85α.
As expected, WT and non-lethal Fam20C mutants (T268M and P328S), but none of the other mutants induced a mobility shift in OPN, consistent with previous reports (Tagliabracci et al., 2012, 2014).
All of these mutants induced a strong reduction of stress fibres in the majority of HeLa cells, and a rounded phenotype with branched protrusions (branching) in 30 40% of cells.
When formulated with alum, the monomeric cysteine mutants induced a similar immune response as the aggregated parental allergens, which is in contrast with data published on Bet v 1.
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