Analysis of Wnt reporter in these mutants indicates that the loss of Dkk2 activates Wnt/β-catenin signaling (Mukhopadhyay et al., 2006).
Analysis of the folding reaction in yeast strains carrying conditional chaperone mutants indicates that incorporation of VHL into VBC requires both functional TRiC and Hsp70.
The loss of nocardicin A production in each of the T domain mutants indicates that all five modules are essential for its biosynthesis.
The reduced stability of both mutants indicates that both the H-bonding and hydrophobic interactions associated with Tyr30 contribute to the protein stability.
Analysis of mutants indicates that the conserved Swc2/YL1 subunit and the adenosine triphosphatase domain of Swr1 are mainly responsible for binding to substrate.
Analysis of mutants indicates that although initial NP formation is grossly normal, cells in the Fgf8-expressing domain undergo high levels of apoptosis, resulting in cessation of nasal cavity invagination and loss of virtually all OE neuronal cell types.
The comparison of the inhibitory activities of N8 and its mutants indicates that the hydrophobic interaction of Met-6 and the electrostatic interaction of Arg-4 contribute most for inhibitor binding.
The EPR analysis of six doubly labeled bR mutants indicates that the cytoplasmic end of helix F not only tilts outwards, but also rotates counter-clockwise during the photocycle.
Examination of residue pairing in our large collection of GB1 mutants indicates that specific side-chain side-chain interactionside-chain side-chaintant to β-side-chain side-chaininteractionsesidue contributions.
Phenotypic analyses of Atg7 mutants indicates that Atg7 disruption renders Arabidopsis (Arabidopsis thaliana) cells hypersensitive to a shortage of nutrients with features of premature leaf senescence, though the mutant is otherwise normal (Doelling et al., 2002).
Analysis of mineral overaccumulation mutants indicates that translocation of minerals to seeds is tightly regulated, and that simply increasing net mineral uptake into the plant will probably not result in seeds with higher mineral concentrations.
