Sentence examples for mutants indicated a from inspiring English sources

Experiments using NICD1 deletion mutants indicated a role for the RAM domain in this process, and either Jagged1 stimulation or expression of a transcriptionally active form of RBP-J in 32D cells also promoted myeloid differentiation (Schroeder and Just, 2000).

Shortened foregut and defective midline cardiac fusion in Foxa2loxP/loxP; Isl1-Cre mutants indicated a role for Foxa2 during ventral morphogenesis.

In addition, analysis of mec-8; fbn-1 double mutants indicated a role for FBN-1 throughout the embryonic sheath in resisting or properly distributing forces that arise during circumferential constriction of the epidermis.

The first description of these mutants indicated a precocious seam cell terminal differentiation that leads to the formation of adult-specific alae during the third molt (Abrahante et al. 1998; Jeon et al. 1999).

Moreover, experiments with flotillin mutants indicate a Golgi-dependent transport of flotillin-2 and a similar trafficking for flotillin-1 [11].

Under these conditions, the wild type strain and the bat1Δ mutant showed higher growth rates than those observed in the double and bat2Δ mutants indicating a catabolic role for Bat2 (Table 2 and Figure 1B, CEN).

In mice, knock-out mutants indicate a redundancy among MMPs and only few MMPs have been found to be required specifically during bone and vascular remodeling and mammary development [2], [6].

The mRNA levels of several G1, but not G2, regulators change in scr mutants, indicating a peculiar role of G1 regulators in the RBR/SCR-mediated pathway that controls stem cell maintenance [73].

These findings, together with the aberrant tendency for swollen knobs to protrude above the ciliary layer in the MKS3 mutants, indicate a defect in the maturation process of OSNs, and consequently a flaw in either the initial organization, or in the maintenance, of the OE.

As loss of branch point C function alone (lane 4) results in only partial exclusion of exon five from BAX mRNA, the near total skipping of exon five seen with these potentially compound mutants indicates a significant contribution of the polypyrimidine tract to correct BAX splicing.

Similarly, copulation attempts were absent in Est-6° mutants, indicating a decrease in courtship vigor.