Sentence examples for mutants in human from inspiring English sources

To increase the efficiency of integration, we mutated the φC31 integrase gene and screened the mutants in human cells in an assay for higher recombination frequency between attB and attP.

In addition, the overexpression of various p53 mutants in human cancer cell lines could also mask the important roles of acetylation in p53 stabilization.

Corresponding mutants in human MKKs showed that they are conserved not only structurally, but also functionally.

Nevertheless, these results show the loss of anti-Bax function in the GSS-associated PrP mutants in human primary neurons.

Here, we have performed an in-depth characterization of the biological responses of the parental NYVAC virus and its recombinant mutants in human cells in vitro.

Epitope mapping was performed using full length and truncated recombinant α-enolase expressed in bacteria and synthetic peptides, results were confirmed by the ectopic expression of the wild type antigen and deletion mutants in human cells (data not shown).

Some of the mechanisms underlying Ig-CSR and SHM have been described by studying natural mutants in humans.

This hypothesis may be tested by elucidating the molecular mechanism of hair loss in cetaceans and the differences in hair loss between cetaceans and Hr mutants in humans and mice.

Here we report the first study using base editor (BE) system to correct disease mutant in human embryos.

However, whether base editors can repair homozygous T>C (or A>G) disease mutant in human embryos remains to be tested.

Nonetheless, the high cytokine induction phenotype of the MAMM mutant in human macrophages and pneumocytes is relevant to the pathogenesis of human influenza virus infections.