Sentence examples for mutants in combination from inspiring English sources

To further evaluate the negative effect of HIF-2α mutations on pVHL affinity, we transiently expressed full-length HIF-2α (WT and representative class 1 and class 2 mutants) in combination with FLAG-pVHL in human embryonic kidney epithelial HEK293a cells that express endogenous PHD2.

Though the nature of that link has yet to be elucidated, we hypothesize that the increased sleep in SdcBG02774 mutants in combination with reduced TAGs may be indicative of a strategy to conserve energy, an idea long postulated as a possible function of sleep [54].

We have used these shak-B mutants, in combination with misexpression of a toxin, to test the function of the chemical component of this mixed synapse.

The authors should simply state the phenotypes of lpoA and mrcA mutants in combination with cpoB are not equivalent, and provide a short discussion of this and what it might mean.

Additional studies are necessary to investigate whether the reduced potency of Halα mutants in combination with wild-type Halβ is reflective of the ability of Halα mutants to bind lipid II, to effectively recruit Halβ for synergistic activity, or both.

Interestingly, although met-1mutants alone have few phenotypes, met-1 mutants in combination with mutations in met-2 (which encodes an H3K9 methyltransferase) have a 'mortal germline phenotype'; that is, there occurs an increased frequency of sterile offspring in each successive generation [ 42].

The latter construct encodes the T790M mutant in combination with the drug-sensitive L858R mutant.

Double balanced stocks of integrin mutants and Dcas1 were crossed to make double heterozygous stocks of each mutant in combination with Dcas, and analyzed for adult viability and visible phenotypes (Table 1).

The authors themselves published an article in 2004 in EMBO journal that uses the same di-sulfide-linked mutant in combination with AFM imaging with or without DTT to observe the shrinking of the pore heights due to pore formation.

Moreover, the relatively mild behavioural phenotype of the Bdr mutant, in combination with the well-characterized synaptic deficit, renders it eminently suitable to examine the role of PNS in the modulation of behaviour.

In conclusion, FTIR measurements of the D2-K317R mutant in combination with Cl /NO3– replacement have provided experimental evidence that the Cl-1 site is structurally coupled with the Mn4CaO5 cluster and that the D2-K317R mutation perturbs the changes in protein structure induced by formation of the S2 state.