The G protein is thought to transmit the gibberellin signal(s) responsible for the normal development of rice internodes and seeds [23], whereas d11 is a novel cytochrome P450 gene mutant implicated in brassinosteroid (BR) biosynthesis [72].
Unlike Vret, the levels of unprocessed precursor RNA from flam are increased in zuc mutants implicating Zuc in piRNA cluster transcript processing.
NOD1 mutants are implicated in disease to a lesser extent than NOD2 mutants.
The dnaQ transposon insertion mutants therefore exhibited an SOS profile similar to recBC mutants, implicating ε in the mechanism of double-strand break formation after nalidixic acid treatment.
A mutant protein implicated in disease can have multiple changes in its behavior in the network.
As we have picked mutants of genes implicated in chromosome stability, mutant alleles that result in a nonfunctional protein, or reduction of function as displayed by decreased strain fitness, or increased sensitivity to DNA-damaging agents, are candidate mutations that might contribute to chromosome instability in tumor cells.
Furthermore, TaHMA2-like expression was significantly reduced in both gpc mutants, implicating a role for GPC in its regulation.
Furthermore, we found that PBAF mutants share this phenotype with hnd-1 mutants, implicating SWI/SNF chromatin regulation in the molecular mechanisms that distinguish SGPs from their differentiated sisters.
BAV has been reported in a number of mouse mutants, implicating Notch, eNOS, Gata5, and Alk2 in the development of the arterial valve leaflets.
Additionally, using rice near isogenic lines and mutants, more genes implicated in controlling flowering time have been identified and positioned into a regulatory network (Brambilla and Fornara, 2013; Itoh and Izawa, 2013; Tsuji et al., 2011, 2013) (Fig. 2).
