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Interestingly, here we show that conditional Ilk mutants have reduced phosphorylation levels of Smad3 in the OFT cushions, which correlated with reduced αSMA expression levels.
r2d21 mutants have reduced female fertility, producing less than 1/10 the normal number of progeny.
Recombinant Der f 7 I157A, L158A, or D159A mutants have reduced IgE-binding activity.
Using secondary screens, we divided these mutants into two groups: In the first group, mutants have reduced endurance to infections but show no change in bacterial growth.
The Phe-266 and Tyr-366 mutants have reduced proteolytic activity indicating a direct participation in the proteolytic reaction, and their possible role in catalysis is discussed.
These data show that r2d21 mutants have reduced viability and defective female fertility that stems from abnormal follicle cell function, and Dicer-1 impacts this process.
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Using western blots and immunohistochemistry, Zeng et al (2007) showed that neurexin mutants had reduced brp expression in larval brain, and reduced synapse density in adult brain [36].
With TOPgal, β galactosidase activity was detected in both Tbx6 wild type (n = 24) and homozygous mutant (n = 14) embryos, although 3 mutants had reduced levels in the PSM (Figure 3Q,R).
fruC mutants had reduced fertility, consistent with previous reports [ 37].
Null mmp1 mutants had reduced viability during larval development compared with controls (w : 60%; mmp1: 17%).
All mutants had reduced unwinding activity compared with the wild-type protein.
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