Exact(1)
Consequently, ENU mutants have often revealed phenotypes that are novel, different, or more robust than the corresponding knockout mutant, including the dominant-negative ClockΔ19 mutant (Vitaterna et al., 1994; DeBruyne et al., 2006).
Similar(59)
In the past, such drug-induced mutant viruses have often not spread very well.
Mutants have been often isolated or generated from different strains and crossings to map those mutants may involve inversions hindering or reducing recombination.
Mutations that reduce the catalytic activity of this enzyme have strong mutator effects, and dnaQ null mutants have severe, often lethal, growth phenotypes, resulting from the extreme rate of replication errors (Lifsics et al. 1992; Fijalkowska and Schaaper 1996).
Most of the identified mutants have not been implicated in TORC1 signaling before, and they often exhibit altered lifespans and growth rates.
Hypomorphic mutations are often informative even for functions of genes of which previously null mutants have been described.
Now the mutants have to battle the ur-mutant, the first mutant of all, the ancient Egyptian potentate En Sabah Nur, smaller and more human-sized than in the comics and played with massive impassivity by Oscar Isaac.
Both papers also show that PINK1 parkin double mutants have symptoms that are indistinguishable from those seen in the single mutants.
Extracts of glyS mutants have altered GRS activities.
White (d/d) mutants have defects in pigment cell morphogenesis and differentiation, whereas albino (a/a) mutants lack melanin.
Various HA-tagged mutants of ephrinB2 (∆6, ∆10 ∆16, ∆19, ∆19 and Y5F) and the Dsh2 deletion mutants have been reported42,66.
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