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Specific mutants have developmental defects, particularly during oogenesis [21], [22], [23].
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This difference could explain why Dync2h1 mutant mice have developmental defects including polydactyly, while BBS mutant mice do not.
Foxc1 null mice (Foxc1-LacZ) and Foxc1 hypomorph mutants (Foxc1-hith) have developmental brain hemorrhages (Kume et al., 1998; Zarbalis et al., 2007).
However, unlike mutants in other RNAi components like Dicer-2 or Ago-2, we report here that r2d21 mutants have striking developmental defects.
rpm-1 mutants have two developmental defects in their mechanosensory neurons, abnormal synapse formation and overextended axons as a result of failed axon termination (Grill et al. 2007; Schaefer et al. 2000).
Using multiple alleles of each gene, we found that ced-3 lf);ain-1(lf) ced-3 lfutain-1 lfe ain-1 lfpic doublepmutantsphavetypleiotropicng developmentalval growth rate, smaller brood size, abnormal adult body morphenotypesgg-layincludingt (accumulation of eggs insidelays aninalarvalugrowthmovement, embrateic lethality, and laid oocytesmallerure to fertilize).
Previous work has shown that each of these types of neurons that make up the tap circuit have developmental defects in rpm-1 mutants.
Pipsqueak proteins are known to have developmental roles (Grillo et al. 2011) and pipsqueak mutants exhibit defects in olfaction (Sambandan et al. 2006).
The nine students all have developmental issues.
Does the parent have developmental disabilities?
"They both have developmental problems," Ms. Ali said.
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