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Analysis of elongation defective mutants has identified epidermal proteins that regulate actin-based contractions, supporting the model that actomyosin based contraction of lateral epidermal cells provides the driving force for epidermal cell shape change [3] [6].
In C. elegans genetic screens for Pat (Paralyzed, Arrested elongation at Two fold) mutants has identified animals with defects in sarcomere assembly, and these have proven a powerful aid in identifying novel focal adhesion proteins and for the investigation of their functions in vivo (for example, see [18] [20], [24]).
Study of liguleless mutants has identified genes with roles in meristem maintenance, leaf polarity, and leaf angle (Moreno et al. 1997; Walsh et al. 1998).
Evaluation of fiberless cotton mutants has identified genes differentially expressed in very young fiber, including transcription factors shown to play roles in fiber development [ 14, 15].
Genome-wide SDL screening of yeast kinase mutants has identified new targets and regulators of kinases (Sharifpoor et al. 2012; Sopko et al. 2006).
Previous analysis of SnTox1 and culture filtrates from SnTox1 knock out mutants has identified a sensitivity locus within a >10-cM interval on chromosome 4B in the ITMI bi-parental mapping population (Liu et al. 2012).
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Studies with deficiency mutants have identified multiple systems that maintain DNA methylation in Arabidopsis [35] [38].
Genetic screens for synaptogenesis mutants have identified key players in NMJ formation and structure.
Investigations of the transcriptome and the proteome of S. typhimurium slyA mutants have identified many loci with altered expression in slyA mutant strains [38], [39].
Phenotypic screens of target-gene mutants have identified several with rhythm-specific circadian defects, indicative of effects on clock output pathways.
Recent in-depth analyses of long-lived mutants have identified non-genetically based reasons for increased longevity [34], thus further supporting the usefulness of the natural systems such as Harpegnathos for ageing research.
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