Exact(7)
We found that homozygous zebrafish mutants for this allele were defective in Notch signaling as indicated by the impaired expression of Notch target genes.
The exon-4-encoded Sdf-1γ C-terminus is thus sufficient for nuclear localization, a finding confirmed by the fact that Sdf-1α and β, functionally equivalent to Sdf-1γ deletion mutants for this region, do not localize to the nucleus.
Mutants for this gene produced fertile pollen but plants were sterile because anthers did not dehisce.
PC2 deletion mutants for this ER retention signal constitutively translocate to the PM [ 18].
By employing deletion mutants for this region, as well as point mutants, they attribute the majority of MDA5-activity generated in EMCV-infected cells to the L-region antisense RNA.
Female mutants for this protein display normal Xist RNA coating and H3K27me3 enrichment on the Xi, but show little sign of DNA methylation at 5′ end of X-linked genes when analysed at around E9.5 E10.5 (Blewitt et al. 2008).
Similar(52)
We created a DMF5 mutant for this residue and showed that, unexpectedly, this TcR had acquired a reduced overall activity although the TcR-pMHC complex was more stable when compared to the TcR wild type complex (increased t1/2).
In contrast, a null mutant for this gene showed decreased tolerance to high-salinity and drought stress.
The Estrrb (≡Errβ) gene, which encodes the orphan nuclear receptor ERR-β, was suggested as a potential candidate for an FGF4-independent signaling pathway, since embryos mutant for this gene die at around 10.5 dpc from severe deficiency of a diploid trophoblast [13], [49].
A gene deletion mutant for this ORF has normal morphology, but is male barren.
Additionally, NCU06102 has two unique nonsynonymous SNPs although a homokaryotic gene deletion mutant for this ORF is available.
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