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We study the mean number of mutants for an arbitrary cell death rate, and give partial results for the variance.
Computational analysis of metabolic fluxes is essential in understanding the structure and function of a metabolic network and in rationally designing genetically modified mutants for an engineering purpose.
There is also a trend in Nkx2.1iCre/+ Ngn3 flox/flox mutants for an increase in circulating Pyy.
We also included the deletion mutants for an additional five yeast genes (HRK1, TPO3, MET7, PNP1 and GPD1), which are HP and whose products are orthologous to specific cancer-drug targets.
Here we show that Drosophila mutants for an intracellular calcium signaling channel, the inositol 1,4,5-trisphosphate receptor (InsP3R) store excess triglycerides in their fat bodies and become unnaturally obese on a normal diet.
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We are currently employing the mutants for a number of investigations of gene function involving conventional and systems biology approaches.
Similar phenotypes were observed in mutants for a variety of ATP synthase and vacuolar protein sorting genes generated in a viral insertion-based mutagenesis screen [70], [74].
The mutants identified in the 1st round screen were arranged into pools of ∼30 mutants for a 2nd round screen in both the chinchilla and mouse models as described above.
Our current study proposes a strategy to generate Drosophila mutants for a certain gene.
TILLING requires a significant amount of time to identify mutants for a large number of genes.
We performed molecular dynamics simulations for each of the mutants for a total time of 50 ns.
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