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In contrast to the dmd and caf mutants, detached myofibres remain viable and form ectopic myosepta in sof mutants, exposing a newly identified pathway that could be targeted in therapy for MDs (Jacoby et al., 2009).
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A thorough study of the outcomes (CO, NCO, BIR) of DSB repair in budding yeast mus81 yen1 single and double mutants exposes a complex system where Mus81 contributes significantly to CO formation after DSB-initiated HR in mitotic cells (Ho et al. 2010).
In Mafb CKO mice, Wave I was delayed, with increased latency in mutants exposed to a 16 kHz pure tone.
Initial genome-wide studies to characterize genetic function in response to DNA damage measured the fitness of deletion mutants exposed to a variety of genotoxic insults (Giaever et al. 2004; Parsons et al. 2006; Hillenmeyer et al. 2008).
Leaves of the pad2-1 mutants exposed to a light intensity of 700 and 1,500 μmol m-2 s-1 for 14 d showed similar anatomy as plants exposed to 300 μmol m-2 s-1 for 14 d containing two tightly-packed palisade cell layers and about 3 to 4 layers of spongy parenchyma.
For instance, by screening the clonogenic potential of a collection of S. cerevisiae mutants exposed to an overtly toxic amount of CDDP, we demonstrated that the molecular cascades elicited by CDDP, CdCl2 and C2-ceramide in yeast exhibit very limited overlaps.
All Rara /– mutants exposed to TCDD consistently displayed a cleft palate.
The aak-2 mutants exposed to four days of anoxia had a significant decrease in survival rate in comparison to control (Table S2, Figure 3B).
The second dataset included a time course representing the transcriptional response of E. coli during acid adaptation and the expression profiling of a compendium of 26 mutants exposed to acid.
This growth inhibition enabled the selection of cells resistant to the effect of naringenin in shaking culture using a library of REMI mutants, exposed to 200 μM naringenin for 21 days.
The daf-16 mutants exposed to three days of anoxia did not show a significant difference in overall survival when compared to that of control (Figure 3A, Table S2).
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