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CRH-1 loss-of-function mutants exhibited abnormal athermotactic behaviour.
let-60 lf) let-60 lfxhibited abnormutantsaging bexhibitedn which their heabnormalents were slightly asymmetrical and over-bent.
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The majority of the genes discussed above were identified using genetic screens in which mutants exhibiting abnormal behavior were isolated.
Mutagenesis was carried out by ultraviolet (UV) irradiation to isolate mutants exhibiting abnormal nuclear morphology in meiosis.
These mutants exhibit abnormal cell patterning within the cerebellum (Lalonde and Strazielle, 2007; Brooks and Dunnett, 2009; Kim et al., 2009; Sheets et al., 2013; Cendelin, 2014).
C. glabrata calcineurin and crz1 mutants exhibit abnormal cell structures compared with the wild-type at 37° or above, but not at 24° (data not shown).
The cdipt hi559 mutants exhibit abnormal villous architecture and disorganized proliferation of intestinal epithelial cells (IECs), with pathologies reminiscent of inflammatory bowel disease (IBD), including apoptosis of goblet cells, abnormal mucosecretion, bacterial overgrowth and leukocyte infiltration.
The acs-20 mutants exhibited abnormalities in the cuticle structure.
A role for Foxa2 in prechordal plate during anterior embryo morphogenesis has also been supported by the phenotype of double Gsc null- Foxa2 heterozygous mutants which exhibited abnormal forebrain morphology similar to that observed in Foxa2 loxP/loxP; Isl1-Cre mutants (Filosa et al., 1997).
Ten Unc mutants that exhibited abnormal locomotion were isolated.
This coordination is most likely achieved via adhesive cues, as disruption of ecdysone signalling affects turnover of adhesion complexes and cytoskeletal proteins in somatic ECs: mutant cells exhibited abnormal accumulation of DE-Cadherin, β-catenin/Armadillo and Adducin.
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