Whereas both hec and spt mutants exhibit short fruits and reduced fertility as a result of disturbed gynoecium development (Alvarez and Smyth, 1999; Gremski et al., 2007; Heisler et al., 2001), the most obvious difference is that hec1,2,3 plants, in contrast to spt mutants, have only minor defects related to gynoecium fusion.
In each of seven independent experiments performed by multiple individuals, dnj-14 ok237) dnj-14 ok237bited shorter lifespan than wild-type N2 wormutants
In other words, we predicted that the I323T (mSlo) mutant should exhibit short-lived single-channel openings as dSlo1A did.
tel1 Δ mutants exhibit abnormally short telomeres (Lustig and Petes 1986) and Tel1 has been shown to associate with short telomeres to promote the recruitment of telomerase and telomere elongation (Hector et al. 2007; Sabourin et al. 2007).
Next we analyzed immunolocalization of pan-twinfilin in auditory epithelia of Whrnwi/wi and Myo15a sh2/sh2 mice as these mutants exhibit very short stereocilia and tips of all stereocilia within single bundles contain myosinVIIa [5].
Over a series of 4 independent experiments performed by multiple individuals, dnj-14 tm3223) dnj-14 tm3223stently exhibited shorter lifespan than wild-type N2 wormutants mean lifespan of the tm3223 strain being 14.0 days (95% consistently.44) comparexhibited8.3 dayshorterCI: 17.5–19.1) for the N2 strain (Fig. 2A).
sir2Δ mutant exhibits shorter lifespan, whereas an extra copy of SIR2 integrated into the genome results in longer lifespan (Kaeberlein et al., 1999).
Analysis revealed that Foxa2 loxP/loxP; Isl1-Cre mutants exhibited significantly shorter rostral-caudal foregut pocket length when compared to somite-matched controls (supplementary material Fig. S4).
Ciliary length analysis in Figure 3F showed that the cells expressing phosphatase-dead mutants of OCRL exhibited shorter cilia when compared with OCRL WT.
37 However, patients with mutant KRAS tumors exhibited shorter PFS, suggesting a negative interaction between panitumumab and oxaliplatin, in line with a previous study.
