NLP7 was isolated by reverse genetics strategy and the nlp7 mutants exhibit a nitrogen-starved phenotype46.
C. elegans DAPC mutants exhibit a unique locomotory deficit resulting from prolonged muscle excitation and contraction.
MD simulations demonstrate that the rather complex modules of VCP/SPICE and their mutants exhibit a high degree of intermodular spatial mobility, which is affected by surface mutations.
Using a fluorescence-imaging-based genetic screen, we found that cngc14 mutants exhibit a complete loss of rapid Ca2+ and pH signaling in response to auxin treatment.
Most strikingly, by far, not all known murine leptin mutants exhibit a defective leptin synthesis and/or secretion.
We find that Gata6 mutants exhibit a complete absence of PrE and demonstrate that GATA6 levels regulate the timing and speed of lineage commitment within the ICM.
Compared to the wild type, iku2 and mini3 mutants exhibit a series of similar phenotypes, such as precocious cellularization in endosperm development, retardation in embryo development, and reduction of embryo size [48].
Both mouse mutants exhibit a cranial neural tube closure defect resulting in an exencephaly.
When presented with an evoked stimulus, however, wnt2 mutants exhibit a large reduction in evoked amplitudes.
Therefore, these three mutants exhibit a higher affinity to ATP, but are less effective in ATP hydrolysis (Figure 5E).
Compared to wild type worms, daf-2 mutants exhibit a two-fold increase in the CARS signal and a three-fold reduction in the autofluorescent signal.
