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These results suggest that the Not4 ubiquitin ligase has both ligase-dependent and independent interactions with hnRNPs and NPC mutants essential for mRNA export.
Seven mutants essential for maintenance of the virulence plasmid are not included in the pWR100 collection, namely ccdA, mvpA mvpT, repB, copA, tapA, and repA (Bahassi et al. 1999; Blomberg et al. 1992; Cevallos et al. 2008; Sayeed et al. 2000).
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We note that use of mutants was essential for this analysis and caution that a mutant transcriptome may include changes not found in wild-type and that XX sperm are only a proxy for XO sperm.
Deleted genes in the three DAF mutants not essential for life.
Approximately 40% of the aggregated proteins from both ncs2Δelp6Δ and ssb1Δssb2Δ mutants are essential for yeast viability.
This indicates that White, the protein absent in the w mutant, is essential for the ethanol-induced courtship disinhibition.
At the end of his talk, Dr. Schick mentioned established repositories for the collection and distribution of relevant mutant strains essential for basic biomedical research.
While ciliary ultrastructure is normal in most mutants, one of the mutant loci is essential for the formation of proper microtubule architecture in the axoneme of pronephric cilia.
Most of the genes affected in the mutants studied are essential for photoautotrophic growth.
Intracellular survival/replication results (Figure 2) are consistent with earlier reports that suggest Δhfq and ΔsmpB Salmonella Typhimurium mutant strains are essential for intra-macrophage proliferation [22], [23], [25].
Efficient clearance of damaged or mutant proteins is essential for cellular homeostasis.
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