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In this scenario, on one hand our work demonstrates a significant contribution of p75NTR signaling to the nociceptive actions of NGF, since the R100 mutants displays a greatly reduced binding to p75NTR.
Furthermore, max2-1, in common with other strigolatone mutants, displays a number of auxin-related phenotypes, which led to the hypothesis that strigolactones act by restricting polar auxin transport.
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The spl28 mutants displayed a necrotic lesion phenotype spontaneously in the absence of pathogen attack.
Kit mutants displayed a lower intrinsic kinase activity relative to PDGFRA mutants, while the KIT Exon 11 deletion mutant exhibited the highest intrinsic kinase activity among KIT mutants.
Substitution of alanine for Arg93 or Arg175 induced a 7 8-fold decrease in inhibition potency, while Arg165Ala, Lys169Ala, Arg17 8-folddecreaseAla thrombin mutants dinhibition 2–4-fold decrease.
CLASP is a key regulator of microtubule (MT) dynamics and bipolar mitotic spindle structure with CLASP mutants displaying a distinctive monopolar spindle phenotype.
Dg mutants displayed a strongly reduced Dys staining (Fig. 3B1-3).
Double pop2-5 ssadh-2 mutants displayed a phenotype characteristic of pop2 mutants (Figure S1).
ΔBAR1 mutants displayed a severe colonial phenotype (Table 1; Fig. 1C).
Recently, we have shown that C. elegans atx-3 mutants display a temperature-dependent motor phenotype [29].
All mutants displayed a similar growth rate as the wild type ST556 in THY broth (data not shown).
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