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While wildtype yeast were not detectably sensitive to the overexpression of Rup1, rsp5-1 and ubp2Δ mutants displayed modest hypersensitivity.
The intensity of the mer defects was comparable to those of the three core components of the Hpo pathway, whereas ex mutants displayed modest phenotypic effects.
These mutants displayed modest (AA79CC +,-) or high activity (AA81CC and AA83CC both +,+); see Figure 1C.
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Unexpectedly, the QacR E90 and E120 mutants displayed only modest effects, no greater than 2.7-fold, on the affinities for the drugs examined (Table 1) indicating clearly that these charged residues are relatively minor contributors to drug-binding affinity.
Wild-type UbcM2 and all of the backside mutants displayed a modest reduction in ubiquitylating activity using K6R Ub.
All of the radiation-resistant and radiation-sensitive mutants displayed similar, modest sensitivities to a brief exposure to bleomycin, suggesting that continous exposure was not the key to their sensitivities.
Surprisingly, the compound displayed modest NLO properties which were strongly affected by its crystal packing features.
Several compounds displayed modest activity and good selectivity for Factor XIa.
The unsubstituted phenyl AMC derivative compound 21 displayed modest activity (MIC, 2 to 4 μg/ml) against resistant strains, but heteroaryl derivatives such as compound 22 demonstrated poor activity against resistant organisms, particularly against Tet M mutants.
WT MEK1 displayed modest S218/222 phosphorylation upon serum stimulation.
Both cell lines displayed modest sensitivity to TNF.
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