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Both Ntn1 trap/trap and Ntn1 −/− mutants displayed highly disorganized commissural axons that were often oriented away from the midline.
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Nonetheless, all the mutants display highly similar cell cycle profiles.
Furthermore, lsk1Δ, lsc1Δ, as well as kinase-dead lsk1-K306R mutants, display highly similar cytokinesis defects.
sll1 mutants display extremely rolled leaves of a deeper shade of green.
This will enable systematic structure-function studies for genes, for which no mutants are available, or more importantly mutants that display highly pleiotropic phenotypes.
For p2gR-TRI-A, more than 70% of the T1 transgenic plants displayed highly clustered trichomes, as expected for try cpc double or try cpc etc2 triple mutant plants [ 47].
All IL23R gene variants displayed highly significant associations with CD.
The Cux2 mutant mice display highly reduced Cux2 protein levels in the brain and variable penetrance and expressivity of the phenotype (Iulianella et al., 2008).
Therefore, hNGFR100 mutants display a highly effective neurotrophic (survival and dependency) activity in both DRG and SCG cultures.
Comparison of our expression dataset with a published dataset in primordial germ cells revealed that the expression of the nonphosphorylatable S83A-HP1γ mutant displayed a highly similar pattern as HP1γ depletion, including targets related to cell cycle, proliferation and growth.
Mutants displayed cleft palate together with several cardiovascular defects, including a highly aneurysmal aortic sac and CAT.
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