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DOI: http://dx.doi.org/10.7554/eLife.01229.006 All of the double mutants demonstrated highly increased fitness over the S. Typhi parent strain and all single mutants, suggesting that epistatic interactions among resistance loci may play a role in determining strain fitness.
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Although all patients had metastatic disease, plasma analyses demonstrated highly variable AFs of mutant fragments.
Although all patients had progressive metastatic disease, plasma analyses demonstrated highly variable allele fractions of mutant fragments.
Embryonal brain tumors demonstrated highly spatially homogenous transcriptomes.
All four SNPs demonstrated highly significant association with gout.
In contrast, Gli2−/− mouse mutants demonstrated a decrease in proliferation mainly in, otherwise, highly proliferative cortical layers [ 38].
Eleven mutants demonstrated X chromosome nondisjunction at 25% or above.
Furthermore, the thr1∆ and thr4∆ mutants of human pathogenic S. cerevisiae strains demonstrate highly attenuated virulence and are not able to survive in vivo (Kingsbury and McCusker 2010a).
The CCI demonstrates highly significant differences.
The corneal tissue demonstrates highly nonlinear mechanical behavior.
Mutants demonstrating normal growth in presence of cerulenin were considered as good candidates for further studies.
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