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Finally, sequence analysis of these four suppressor mutants demonstrated a lack of the vtc1-1 mutation.
Dramatically, at e13.5, Foxc1 −/− mutants demonstrated a twofold reduction of ventricular zone proliferation, compared to e13.5 wild-type animals.
In contrast, Gli2−/− mouse mutants demonstrated a decrease in proliferation mainly in, otherwise, highly proliferative cortical layers [ 38].
DOI: http://dx.doi.org/10.7554/eLife.09406.006 In contrast to their cardiac phenotypes, ttna mutants demonstrated a sharp division in development of skeletal muscle disease.
Consistent with the pCYCB GUS results, the exocyst mutants demonstrated a reduced cell production rate that correlated with the reduced root growth rate.
pxy er mutants demonstrated a height defect but this was an additive phenotype as average plant height was a combination of the reductions observed in the single mutants (supplementary material Figs S7, S8).
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POL32 has been associated with roles in DNA damage repair and chromosomal DNA replication, and previous work examining POL32 null mutants demonstrated an increased resistance to rapamycin17.
Here blr mutants were found to form a continuous ring of vascular tissue, while bp blr double mutants demonstrated an enhanced blr phenotype as cells in the continuous vascular ring failed to differentiate and contained small, densely stained cells where xylem cells with secondary cell walls formed in wild type plants [ 3].
In an in vitro study, these two types of EGFR mutants demonstrated an enhanced TK activity in response to EGF and increased sensitivity to inhibition by TKI, although the biological activity between tumours with L858R and those with deletions was different (Paez et al, 2004; Pao et al, 2004).
Fgfr2b-/ mutants demonstrate a genetically reproducible severe anorectal malformation, characterized by a shortened perineal body, an absence of pelvic rectum, and no visible distal recto-urinary fistula as shown in figure.
Figure 3 shows fast increase of algal cells of wild type (curve 1) after the lag-phase (1st day), as measured by F O. PC Mut2 (curve 2) and PC Mut4 (curve 3) mutants demonstrate a lower growth rate during investigation period.
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