Sentence examples for mutants decrease the from inspiring English sources

The simulations suggested that the L10F and L10F/N88S mutants decrease the binding affinity of nelfinavir, whereas the L90M mutant increases the binding affinity.

The single mutants decrease the interaction between ADAR2 and WWP2 whereas the interaction was completely abolished with the double mutant.

These DUB mutants decrease the cellular ubiquitin pool most likely contributing to the exacerbated APC/C temperature-sensitive phenotype (Penney et al. 1998; Verma et al. 2002) (see discussion).

All mutants decreased the free energy gap of the wild type RC (~ 890 meV), i.e. destabilized the P+QA− charge pair by 60 110 meV at pH 8.

As for Y71, TSSS, and T206, we found that all the phospho-deficient mutants decreased the dynamics, growth speed, and growth length of microtubules, whereas the phospho-mimic mutants either maintained or promoted the dynamics, growth speed, and growth length of microtubules (Fig. 1C E).

Most significantly, all mutants decreased the ligand binding affinity as evidenced by their increased KM values to all tested substrates.

However, these mutants decreased the ratio of Aβ40 Aβ42 at each point assessed, reflecting an absolute and relative increase in Aβ42 production compared with controls.

Indeed, wild-type and phosphomimetic NBR1 mutants decreased the proportion of fibers containing protein aggregates as compared with muscles transfected with nonphosphorylable NBR1.

The CtXR mutant decreased the biocatalyst's performance, suggesting use of the NADPH-preferring wild-type enzyme when (semi- aerobic conditionsemi- aerobic.

This is in full agreement with the SMD simulation results that showed the Y126F mutant decreases the success rate of UMP dissociation trajectories by 50% and increased the success rate of dUMP dissociation trajectories by 100% (Fig. S8).

However, combination of gRNAs complementary to both WT donor and deletion mutant decreased the rate of homology-directed recombination, but did not significantly decrease the mutation rate introduced by this system.