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Synapse loss is an important part of normal nervous system development [38], and the reduced synapse number previously observed in neurexin mutants could represent impairment in initial synapse formation or destabilization and subsequent loss of synapses.
We speculated that the hyperphagia detected in 6-month old mutants could represent a failure to reduce food intake after the rapid growth period, as the 7-week old mice were still growing and had a higher ratio of food intake to body weight than older mice.
This outcome suggests that condition-specific expression profiling of deletion mutants could represent a systematic approach to identifying bona fide target genes for uncharacterized TFs.
Because we identified components of the ABA, ethylene, and auxin pathways, the remaining unidentified AR mutants could represent factors in the ABA, auxin, or ethylene signaling cascades or in an unanticipated response pathway.
Similar(55)
The 68 genes identified as variable in both the wild-type and the over-expressing mutant could represent intrinsically variable or noisy genes in the tissues and conditions examined.
We acknowledge that lipofuscin granule accumulation following overexpression of pathogenic VCP mutant transgenes could represent a byproduct of proteotoxic stress caused by defects in the UPS or autophagy/lysosome pathways that eventually lead to the transformation of proteins into non-degradable products.
Therefore, sug-h mutants could be valuable for practical applications and nutritional aspects.
Thus the electron uptake rate for ΔcymA and the menC mutant (∼20% of wild type) could represent an upper boundary for electron transfer between MtrA and FccA in the presence of physiological flavin levels.
However, they do not have the constricted neck of multiheaded pits observed in dynamin mutant cells and at least some of them could represent a clustering of shallow or U-shaped pits.
The small variations of the ratios could represent experimental error, small idiosyncrasies of individual mutants, or a not-quite fully rate-limiting chemical step for the mutants with the smaller ratios (Table 3).
Expression of Cx43 mutants T154A or Y17S resulted in the formation of protrusions which could represent an intermediate stage which would normally lead to radial spreading.
More suggestions(15)
changes could represent
mutants could serve
mutants could pave
mutants could provide
mutants could differentiate
mutants could affect
mutants could have
mutants could live
mutants could mask
mutants could be
mutants could survive
mutants could form
mutants could emerge
mutants could grow
mutants could depolymerize
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