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Our findings demonstrate that BCR-ABL1 comutantsmutants confer different levels of TKI resistance, necessitating rational treatment selection to optimize clinical outcome.
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The performance of the method and the validity of using the eigenvector associated to the first eigenvalue were previously tested quantitatively on a series of mutants conferring different stabilities to a set of proteins [29].
It was also found that R248Q mutation could accelerate onset of all tumor types and shorten the survival of mice, thus suggesting that hotspot mutants may confer different type and magnitude of GOF effects.
It is possible that other mutant alleles may confer different risks for recurrence.
The effect of arrangement and sex by arrangement interaction indicates that different arrangements confer different fitness benefits relative to the mutant chromosome and that this effect depends on the sex of the mutant parent.
Do different languages confer different personalities?
Different traits confer different rates of survival and reproduction (differential fitness).
IgH class switch recombination (CSR) causes expression of different immunoglobulin isotypes which confer different effector functions.
The different mutations confer different levels of resistance to isoniazid.
Our second conclusion is that different aneuploidies confer different phenotypes.
Despite two mutant sites (G to A, G to D) were observed at PKC domain, it is possible that several amino acid variations in the C-terminal regulatory region would confer different patterns of interaction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com