In contrast, however, vdpkaC1 mutants exhibit both reduced virulence, and under certain growth conditions enhanced microsclerotia production [ 16].
Our findings demonstrate how limiting nutrient conditions enhance the proliferative potential of PTEN mutant cells, independent of additional genetic alterations.
The up-regulations of vacuole-located proteins may imply that autophagy in the cells of these long-lived mutants is enhanced to maintain survival in low nutrient conditions such as SDC medium.
The conditions that dictate the isolation of C. elegans mutants exhibiting enhanced pathogen susceptibility (eps mutants) or enhanced pathogen resistance (epr mutants) depend on the killing mechanism of a given pathogen.
Previous studies have shown that sterile mutants have enhanced resistance to pathogen toxicity and are protected under conditions of low oxygen [ 7, 8], which is regulated by daf-16-dependent and -independent manners, respectively.
vvd mutants display enhanced carotenoid pigmentation in response to light.
In contrast, Dkk1d/dEn−/− double mutants show enhanced digit phenotypes not seen in either single mutant, which indicates that Dkk1 and En1 interact in negative Wnt7a regulation (Adamska et al., 2004).
Open image in new window Figure 2 lsy-2 mutants show enhanced RNAi interference and display transgene silencing.
The nonphosphorylatable S184A containing Bax mutants have enhanced stability to proteolysis, which may further enhance the proapoptotic function of Bax.
Moreover, as compared to GeoTF16 parental enzyme, both GeoInt3 and GeoInt4 mutants revealed (i) enhanced biobleaching performance, (ii) improved adaptability to alkaline conditions, and (iii) better activity for broader pH range.
