Furthermore, combination of clemizole with SCH503034 decreased the frequency of drug-resistant mutants, compared with treatment with either drug alone.
The binding was consistently stronger in KO-AMA1 and KO-AMA1/KO-AMA2 mutants compared with parental line, indicating that these mutants upregulated a MIC recognized by RON2L1.
Although Wnt/β-catenin target mRNAs were more abundant in mutants compared with controls, the amount of nuclear activated β-catenin protein was dramatically lower in mutants compared with controls.
Our binding data indicated a significant impairment of Amsacrine binding energy in the two mutants compared with the wild type.
The first type involves the characterization of mutants compared with wild-type zebrafish at a given stage of development.
Furthermore, in GSEA analysis conducted over the gene expression of the CRC cohort, we could identify several gene sets upregulated in GOF p53 mutants compared with the rest of the p53 mutants.
Kindling-induced granule cell axon sprouting as measured by the Timm stain was also attenuated in homozygous null mutants compared with +/+ mice, with an intermediate effect in +/- mice.
Figure 3 Average leaf bronzing index (LBI) scored after exposure to Fe toxicity on seven selected mutants compared with the JHN wild type.
In leaf sheaths and internodes, no significant increases in soluble sugar levels were observed in the two lse mutants compared with WT plants (Figure 5C F).
and revealed significantly decreased levels in all preparations expressing PrP mutants, compared with that of PrP-WT (Fig. 9).
In contrast, there was no apparent difference in MHP1 expression in any of the mutants compared with the wild-type control (data not shown).
