Sentence examples for mutants cause severe from inspiring English sources

Unfortunately, many mutants cause severe developmental defects and are not suitable for longevity analysis as they produce sick individuals.

The loss of several HD-ZIPIII genes, as in the case of the phb phv rev triple mutant, causes severe developmental defects, including consumption of the apical stem cells (Emery et al., 2003; Prigge et al., 2005).

To understand the pathogenesis of this novel virus in pregnancy, we analyze the chemokine and cytokine profiles, viral load and histopathological changes in placental cell line and BALB/c mice infected by the wild type pandemic influenza A(H1N1) 2009 virus, which is a clinical isolate from a patient with mild disease, and a D222G mutant, which can cause severe clinical outcome.

For example, knockout mutants of hlyX are unable to survive in lung epithelium, sequestered lungs or tonsils [29]; dmsA mutants are attenuated in acute disease [25]; and asp mutants cause less severe lung lesions than the wild type organism [24].

Certain Abd1 temperature-sensitive mutants cause a severe growth defect at the restrictive temperature, and a screen for suppressors of this phenotype identified SAM synthase, the enzyme which synthesizes the methyl donor SAM as a critical activator of cap methyltransferase activity [ 31].

In fact, these inhibitors paradoxically potentiate RAF/MEK/ERK signaling in RAS-mutant cells [63]– [65], and may cause severe adverse effects when given to patients with RAS-mutant cancers.

Recently, using a hamster model of infection, it has been demonstrated that either TcdA or TcdB alone, produced by isogenic mutants of C. difficile, may cause severe disease [ 14].

The mutant H956A, in particular, appears to cause severe disruption to protein folding in addition to the loss of enzymatic activity.

Therefore, our findings clearly demonstrate why mutant mitochondrial tRNATrp is able to cause severe COX deficiency as one of common clinical phenotypes.

This study on the relationship between internodal length and conduction velocity in myelinated peripheral nerves exploited a mouse whose Schwann cells express a mutant periaxin protein that does not cause severe demyelination yet still retains the retarded elongation phenotype of the periaxin-null mouse [ 9, 18].

High concentrations of mutant mtDNA can result in a variety of mitochondrial disorders, which can cause severe suffering and premature death.