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A mechanism implemented by FMTS to allow the user to set equivalent mutants can help in this task.
Conditional knockdown mutants can help validate new drug targets, but the analysis of individual mutants is laborious and time consuming.
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For each of these inherited disorders, a genetically defined mouse mutant can help identify the key molecular defects in excitability and plasticity in the developing epileptic brain, uncover new molecular targets for therapy, and serve as a reproducible biological test system for experimental strategies to prevent or reverse the onset of seizures.
Furthermore, when the orphan activity is associated to a specific phenotype, screens of systematic knockout mutant phenotypes can help in identifying candidates (Aghaie et al., 2008).
These mutants can also help clarify patterns of evolution between VS and UVS visual systems in birds.
The difference between these models also illustrates how having more than one mutant allele of Apc can help to dissect the functions of this multifaceted gene.
Although not effective on its own in rescuing mutant CFTR protein, EGCG can help conserving F508del-CFTR rescued at the PM when added during the period in which cysteamine was removed from the system.
Antibodies are not the only peptides that can help clear mutant protein aggregates.
Even if the resolution of most QTLs is very low, the linkage information can help to connect the phenotype of gene-indexed mutants to agronomic traits.
Subcellular localization of proteins can help elucidate functional changes between wild type and mutant POLA2+1747.
STM can help identify the function of genes by monitoring the phenotype of single-gene mutants.
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