Sentence examples for mutants at this from inspiring English sources
Some of the mutants at this locus display developmental abnormalities.
The expression of Shh was considerably reduced in the first molar epithelium of Lrp4 and Wise mutants at this stage (Figure 6F, 6H and 7D') suggesting that loss of Shh signaling is linked to the molar fusion process.
Another way to test the significance of the T426 site is to co-express the KaiC mutants at this site with KaiCTST in vivo and assess whether the mutant KaiCs affect or disrupt the rhythmicity imparted by the wild-type KaiC.
An identical expression pattern was observed in PGK Cre Dbx1DTA embryos, although the antero-posterior extent of the various domains appeared reduced compared to wild-types (Fig. 4E H), consistent with the smaller size of mutants at this stage (see Fig. S2A, B).
The number of Foxa2+-only cells is relatively low in both controls and mutants at this developmental stage.
Although a statistically significant difference was observed at P20 (supplementary material Table S2), this might be attributable to a smaller cerebellum size of mutants at this stage.
Since CRC expression began in stage 6 and no morphological differences were observed between the wild type and crc single mutant at this stage13, flowers older than the stage 7 were manually selected for and removed using a dissecting microscope (Supplementary Fig. 11a-d).
The amino acid side chain of a mutant at this position would point into a hydrophobic niche that also accommodates the side chain of L574 from another monomer.
However, the possibility that Detrick-1 represents a reversion mutant at this locus from Detrick-2 cannot formally be excluded, but since it represented the dominant morphotype in the 1952 Detrick vial we believe this is unlikely.
In fact, E650R is the only mutant at this site that conducts appreciable current with strontium activation.
ChU-B produced by S. cerevisiae retained ~20%and~10%0% of its initial activity at physiological pH with DMP and ABTS as substrates, respectively, whereas the activity of parent type (OB-1 mutant) at this pH was negligible [ 31].
