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The parent compound (1) was as effective against 10 nucleoside and non-nucleoside resistant HIV-1 RT mutants as it was against the wild-type enzyme.
A particularly useful application has been the construction of conditional knockdown mutants as it provides a genetic approach to study genes whose deletion prevents growth or causes death of the bacteria.
These processes may attenuate the infectivity of generated mutants, as it has been known for more than two decades that prolonged in vitro cultivation reduces the infectivity of B. burgdorferi [26].
In spite of inducing gene expression and glycerol production, expression of CaZF could not provide equivalent salt-tolerance to hog1 and cnb mutants as it did in wild type cells.
This could be protective of Purkinje cells in late stage mutants, as it has been shown that the transection of the climbing fiber inputs from the olive is protective in ischemia [25].
It also suggests that A. thaliana is suitable for conducting pathogenicity assays with future mutants as it is easier to handle this well-established plant model system.
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A genetic map is a systematic catalogue of mutants as much as it is a theoretical model of the fly's genetic system (cf. Weber 1998b).
It is required for autophagy, as AMPK mutants as well as AMPK inhibition suppress autophagy.
Richard Eyre described Mutants as: "extraordinarily thought provoking".
Similar method was employed for the extraction, purification and cleavage of the three mutants as well.
It has been elucidated that individual phytochromes display both unique and overlapping roles in rice photomorphogenesis by characterization of all rice phytochrome mutants including single mutants, all combinations of double mutants as well as triple mutants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com