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However, mex mutants are viable, albeit with a reduced growth and starch excess phenotype46.
Plants homozygous for these mutant alleles were identified by PCR analysis, showing that pbrp2 mutants are viable (data not shown).
All alleles clearly demonstrate that adult Smad8 homozygous mutants are viable and fertile.
The homozygous mutants are viable and fertile allowing us to generate a maternal-zygotic MZezh1ul3/ul3 line used for further phenotypic studies.
Homozygous null mutants are viable and fertile and have no major developmental defects.
Both mutants are viable and at 20°C display a relatively normal morphology, behavior, and development.
Rosa26 homozygous mutants are viable although they are recovered at a lower than expected frequency [21].
Sans mutants are viable, fertile, and mutant follicle cells appear to form microvilli, indicating that Sans is dispensable for fly development and microvilli morphogenesis in the follicle epithelium.
Previous work had also reported that yeast ERG3 mutants are viable but cannot grow on non-fermentable carbon sources [24], [33], [35].
Unlike homozygous Dll1tm1Gos mutants, homozygous C3.Dll1C413Y/C413Y mutants are viable, although only 32% of the expected homozygous animals are alive after weaning.
However, UNG mutants are viable in all species, from bacteria [8] to yeast [9] to worms [10], while mice lacking the catalytic domain of UNG2 are viable and exhibit relatively minor abnormalities [11] [13].
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