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Unlike wild-type Chd5, Chd5-PHD mutants are unable to induce differentiation or efficiently suppress the growth of human neuroblastoma in vivo.
Zebrafish lkb1 (stk11 hu1968) mutants are unable to cope with the energetic stress induced upon yolk depletion and fail to adapt their metabolism to lower nutrient levels.
This choice is supported by earlier results showing that the K8A and K229A mutants are unable to bind short C-terminal peptides of HSP70 and HSP90, respectively34,35, even though it must also be mentioned that the effect of K8A in mouse HOP has been reported not to affect the binding to HSP70 in NIH3T3 mouse fibroblasts despite its 98% sequence identity with human HOP36.
che-1 mutants are unable to chemotax to NaCl yet show wild-type chemotaxis to NH4Ac.
BvrR/bvrS mutants are unable to multiply intracellularly and are avirulent in the mouse model [4].
In many species, ppk mutants are unable to survive during stationary phase [55].
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Two Ser mutants were unable to grow anaerobically on fumarate, nitrate or nitrite.
Two other Ser mutants were unable to grow anaerobically on all compounds tested as sole terminal electron acceptor.
Afh mutants were unable to adjust their time-based decisions in response to the different probabilities of reward delivery after different delays.
However, Δefg1 and Δcph1/Δefg1 mutants were unable to filament and did not form biofilms, but rather sparse monolayers of loosely attached elongated, rod-like, cells.
Additionally, the mutants were unable to distinguish between rough and smooth textures.
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