Sentence examples for mutants are selectively from inspiring English sources

Together these data indicate that the majority of the viable mutants are selectively neutral and that ribavirin acts in a random fashion across the genome.

Given the results of the present study, the fact that NSCLC mutants and glioblastoma mutants are selectively inhibited by erlotinib and lapatinib respectively [ 3] seems unlikely simply to reflect stabilization of different conformational states of EGFR-TKD in the two cancers (active for NSCLC, inactive for glioblastoma).

We assayed lobeline responses in the null poxn ΔM22-B5 mutand and in transgenic strains in which the mutant defects are selectively rescued in different tissues (Boll and Noll 2002).

Since there is no evidence that the proteasome itself can have oncogenic function or is regulated by oncogenic RAS, this is presumably an example of non-oncogene addiction : RAS mutant cells are selectively dependent on proteasome function to deal with proteotoxic stress resulting from RAS-driven transformed growth, possibly quite indirectly.

To address in greater detail whether mutant KRAS cells are selectively sensitive to proteasome inhibition, we assessed the impact of several small-molecule chemical inhibitors of proteasome function on cell viability and apoptosis in the HCT-116 isogenic cell line system.

Our immunocytochemical results (Fig. 2) suggest that in dlg mutants, GluRIIB-containing receptors are selectively lost without any compensatory increase in GluRIIA-containing receptors.

We previously proposed the utility of IN mutant lentiviral vectors that are selectively activated by complementary LEDGF/p75 variants, and our initial modifications in human immunodeficiency virus type 1 IN and LEDGF/p75 supported about 13% of wild-type vector transduction activity.

Ruan et al. also found that striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to MC II III inhibition [32].

How this gene selectively perturbs neurons during ALS is not well understood, although the accepted view is that neurons are selectively sensitive to mutant SOD1.

(B) According to the newly developed approach, the mutant mtDNAs in the oocyte or zygote are selectively eliminated by mitochondrion-locating TALENs.

Unexpectedly, we found that in siRNA-deficient mutants of species from eudicot, monocot and moss MIR159/319 miRNAs are selectively up-regulated.