Sentence examples for mutants are retained from inspiring English sources

In contrast, some OCAI mutants are retained at the ER without further traffic to the Golgi compartment and degraded by ER associated degradation processes [23], [24].

Regardless of this fact, down-regulation did yield an Opi− phenotype so these mutants are retained in our dataset.

Truncated and misfolded opsin mutants are retained in the ER membrane where they do not assemble correctly, but can aggregate or undergo ERAD (ER-associated degradation) [ 33, 34].

Because one unique feature of the phage-based approach is that temperature-sensitive mutants are retained, we have carried out a genome-wide study of S. aureus genes involved in withstanding temperature stress.

The mechanism through which mutations in ATP13A2 cause KRS is not fully understood, although it has been previously shown that the wild-type protein is located in the perimeter lysosomal membrane of transiently transfected cells, while the unstable truncated mutants are retained in the endoplasmic reticulum and degraded by the proteasome (4).

The acidic stability of enzyme was significantly enhanced after mutation, and 45 92% of initial activity of mutants was retained after incubation at pH 4.5 and 25 °C for 24 h, while that for wild-type was only 39.5%.

They felt that 11 of 12 mutants were retained in the ER.

Immunofluorescence and immunoblot studies demonstrated that these recessive mutants were retained in the endoplasmic reticulum [ 21, 22].

Live imaging of the mutant proteins showed that similar to Rho(P23H -GFP, both double mutants were retained in the ER and no clear P23H -GFPmbothe localization was observedouble.  1C).

Although a multisite binding mechanism in mutants is retained, the enzyme is exquisitely sensitive to the minor structural changes in the binding pocket introduced by the point mutations S119A, I369F, I369L, A370L, and A370V.

74 % (58,407 in number) of the unigenes from 21 mutants were retained after filtering for a minimum depth of 10 reads per unigene and the maximum number of unigenes (40,979) fall into 11 50 read depth class (Fig.  3c).