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We also showed that the barrier defects of acs-20 and acs-20 acs-22 acs-20 acs-22 acs-20 acs-2220, acs-22, and humutantsp4 traregenes.
Recombinant PINK1 was previously localized to mitochondrial cristae [6] or outer membrane [19], impaired respiratory activity and oxidative stress are detectable in patient tissues, and PINK1 deficiency phenotypes in Drosophila melanogaster mutants are rescued by factors affecting mitochondrial dynamics [11], [12], [13].
We propose that, after replication blockage, Inv rep mutants are rescued by the SOS-induced DinG and UvrD helicases.
Therefore, spc24 mutants are rescued specifically by growth on nonglucose carbon sources and not generally by slowing cell growth rate.
Interestingly, yeast Top2 mutants are rescued by expression of the Drosophila or human Top2 protein (Wyckoff and Hsieh 1988; Jensen et al. 1996), illustrating the strong functional conservation among eukaryotic type II topoisomerases.
Consistent with these findings, PB has been implicated in the splicing of mitochondrial introns as the respiratory deficiency of dhh1 ∆ and lsm6 ∆ mutants are rescued by deletion of the self-splicing mitochondrial introns (Luban et al. 2005).
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Interestingly, the mislocalization of Myospheroid in Rac1 mutants is rescued by hyperthermia, involving the heat shock protein Hsp83.
We further examined whether defects in the flying ability of tw mutants were rescued by overexpression of the tw gene.
Moreover, the barrier defects of acs-20 and acs-20 acs-22 acs-20 acs-22 acs-20 acs-22-20, acs-22, or humutantsp4 transgenes.
Expectedly, homozygous porinA2 (A2) phenotype was strongly suppressed by Drp1 overexpression or Marf knockdown (Figures 5B and 5C) and the flight disability in porin mutants was rescued by Drp1 overexpression (Figure 5D).
Stress sensitivity, reduced energy stores, and CREB target gene expression in TORC mutants is rescued by neuronal TORC expression [4], indicating that CREB activity in neurons regulates energy metabolism in flies.
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