Sentence examples for mutants are largely from inspiring English sources

Consequently, these mutants are largely trafficking-deficient.

Using stringent statistical criteria (see 'Methods'), we found that the genes regulated by osr mutants are largely overlapping with each other and with wild type ORGs (Figure 1B, Tables S2, S3, S4, S5, S6).

In the present study, we have used this approach again to successfully solubilize the insoluble V22-SH3 and three other insertion mutants, and show that all four insertion mutants are largely unfolded without stable secondary structures and tight tertiary packing by quick CD and NMR characterization.

Importantly, the 3R and 5E mutants are largely rescuing the phenotype of the complexin I-III triple KO.

Consequently, the cardiac defects reported in Hey2 mutants are largely different from those seen in Robo1 Robo2 animals.

Together these observations indicate the increased size of hepatocytes and liver in tsc2 vu242/vu242 zebrafish mutants are largely due to the elevated level of TORC1 activity during early larval stages.

These data support the conclusion that the global distribution of euchromatin and heterochromatin in Slbp mutants is largely unaltered in larval endocycling tissues.

Further, the localization of both mutants was largely diffuse.

Instead, vessel growth in homozygous mutants was largely restricted to the boundary regions between neighboring hindbrain segments.

When it was substituted by 19 other natural amino acids, the voltage dependence of most mutants was largely affected.

By contrast, DSB formation in rec8Δ mutants was largely restricted to small chromosomes and the vicinity of Red1 clusters.