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This indicates that apc2 mutants are capable of delaying cell cycle progression following centrosome misorientation.
Notably, a BBA64 innate immune evasion function is inconsistent with our previous finding that intradermal needle-inoculated bba64 mutants are capable of establishing an infection in mice [33].
By contrast, in A. nidulans, null barA mutants are capable of forming relatively normal sporulating colonies despite defects in maintaining axes of hyphal polarity [15].
While the vast majority of missense mutations yield nonfunctional channels, some truncated mutants are capable of forming functional channels [7] [10].
These data suggest that class IV mutants are capable of forming translocons but the slow kinetics of the channel formation allows cytochalasin D to be effective prior to ExoU translocation.
Since the remaining RFM mutants are capable of restoring genomic methylation, our results suggest that the central portion of the RFTS domain (amino acids 437 586) is tolerant to amino acid substitutions.
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Indeed, artificial point mutations at codons 61, 69 and 137 of HBx have been shown to result in a marked loss of transactivation capability (Kumar et al, 1996), whereas C-terminally truncated HBx mutants were capable of enhancing the activation of cell proliferation and transformation (Ma et al, 2008).
When mixed 1 1 with a wild type partner, none of the mutants were capable of assembly.
Both mutants were capable of binding to mitotic chromatin (Figure S3).
When mixed 1∶1 with a wild type partner, none of the mutants were capable of assembly.
We next tested whether any of the DAT tetraCys mutants were capable of undergoing PKC-mediated downregulation.
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