Sentence examples for mutants are attenuated from inspiring English sources

However, some mutations have no impact on intracellular growth, leading us to hypothesize that these F. tularensis mutants are attenuated because they induce an altered host immune response.

Furthermore, these SodA mutants are attenuated in their ability to cause death and to persist in vivo [4].

In order to determine whether any of the hypercytotoxic mutants are attenuated, BALB/c mice were infected with each of the 28 transposon mutant strains.

For example, knockout mutants of hlyX are unable to survive in lung epithelium, sequestered lungs or tonsils [29]; dmsA mutants are attenuated in acute disease [25]; and asp mutants cause less severe lung lesions than the wild type organism [24].

It has been reported that non-motile and non-autoagglutinating C. jejuni mutants are attenuated [37], and we hypothesized that these phenotypes may have changed during passage in mice.

Most monomorphic mutants are attenuated in virulence (Sudbery et al., 2004).

The strong WUS expression in the crc knu double mutants was attenuated by either activation of YUC4 or removal of TRN217 (Fig. 7j).

A total of 62 mutants were attenuated when checked individually, and 25 unique single transposon insertion mutations were identified from this group.

Moreover, shortly after entering DD, when mice were not under a controlled light-dark schedule, the differences in sleep between wild-types and mutants were attenuated, indicating that light and/or light-dark cycles may have a disrupting effect on the physiology of sleep in Afh mice.

It also emphasized that although ORF75c− mutants were attenuated, they remained replication competent.

In contrast, septin mutants were attenuated in filament formation (Fig. 9A).