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Both mutants are associated with sensitivity to erlotinib [8], [9].
These mutants are associated with a transcriptome that is highly similar to a wild type transcriptome.
Furthermore, in agreement with previously published data smg-1 r861 smg-1 r861nullare associated with a fully penetrant protruding vulva phenotype (94%; n = 205), while this phenotype was only observed in 31% (n = 969) of smutantsaretreassociatedls.
These mutants are associated with the condition of hypogonadotropic hypogonadism (HH) in humans and have also been demonstrated to be uncoupled from the Gq/11 pathway, as evidenced by their inability to stimulate inositol phosphate formation [38].
Circumstantial evidence suggests that ATP is the in vivo donor, as only excision using ATP as the donor is enhanced in the TAM RTs [13], and the TAM mutants are associated with AZT resistance in cell culture-based HIV replication assays.
Genes down-regulated in rx3 -/- mutants are associated with circadian rhythms (e.g. rorb, rorab), and metabolism (e.g. adh8b, aldh1a3).
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Previous studies using immortal and cancer-derived cell lines indicated that the oncogenic activity of cancer-associated FGFR mutants is associated with both their ability to promote cell proliferation and to exert prosurvival activity (6, 7, data not shown).
Our results suggest that deafness in pirouette mutants is associated with loss of GRXCR1 function in modulating actin cytoskeletal architecture in the developing stereocilia of sensory hair cells.
Functional studies showed that all mutants were associated with an inward current.
Sex reversal in both mutants is associated with reduced phosphorylation of p38 MAPK and GATA4.
These large-scale changes in rec8Δ mutants were associated with markedly narrower Red1 peaks.
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