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Exact(8)
Overall, cholate feeding lowers serum cholesterol levels in ATP8B1 mutant mice compared to control-fed mutants, and there are diet-genotype and diet-sex interactions (Table 1).
Since the AVC constriction is unusually wide in Tbx3-null mutants and there is ectopic activation of the chamber genetic program, we analyzed whether the pattern of cell proliferation was altered in these mutants.
First, Dll1, a direct target of Tbx6, is down regulated around the node in Tbx6 mutants and there is a subsequent decrease in nodal signaling, which is required for laterality determination.
Similar to the situation with the color mutants in the B5233 background, the larvae darkened shortly after inoculation with spores of color mutants, and there again appeared to be a positive correlation between the darkening of the infected larvae and the pathogenicity of the strain (Figure 8).
Also, some dHbm marker genes are not expressed at all in mutants, and there is no subnuclear division of habenular neuropil domains.
No transcripts for AtSRP2 and AtSRP3 were detected in the corresponding mutants, and there was no apparent compensation of AtSRP2 transcript levels in the atsrp3 mutant, or vice-versa.
Similar(52)
Taken together, our results provide important clues with respect to explaining the biofilm-deficient phenotype of a S. aureus sarA mutant, and there may in fact be a common theme that ties them all together.
ND13 and NA10 had relatively more activation compared to the ND13(N51S) mutant and there was only a significant overlap on activated genes between ND13 and NA10 (Figure 1).
Because the electron micrographs of McVittie (1972) suggested that the B-tubules fail to close in this mutant and there is no evidence that kinesin motors affect B-tubule closure in any organism, we re-examined the cells by electron microscopy after high-pressure freezing and freeze substitution (O'Toole et al. 2003).
The heme c reduction phase was almost fully suppressed (we note that the residual cytochrome c reduction kinetics seen in the absence of any inhibitors must have come from the half of WBS BN containing the equivalent of H198N, as we also observed such residual activity in the H198N mutant) and there were no signs of any phases of heme b reduction or re-oxidation.
We found that the SSR marker Discs Large robustly stained the postsynapse in syp mutants, and that there was no change in SSR width between syp mutants and controls (supplementary material Fig. S2E).
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