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Our results provide a direct link between the structural changes in the mutants and specific spectral changes observed in the NRVS data.
This demonstrates that the array-based approach is well suited to identifying nuclear genes relevant for regulating the general RNA metabolism (group I mutants) and specific plastid RNA transcripts.
Using a variety of C. albicans cell wall mutants and specific ligand blocking experiments, the authors demonstrated how multiple receptors, including Dectin-1, TLRs and the mannose receptor (MR), were required for the recognition of invasive fungal particles, which in turn was essential for efficient clearance of the infection 49.
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For example, midgut sporozoites in day 13 of NF54, ORF1-specific mutants and ORF2-specific mutants showed distribution of MAEBL on the surface of the sporozoite (Figure 2).
Recently, several specific root mutants and root-specific genes have been identified and characterized in maize and rice.
Our previous binding studies using SU-Fc deletion mutants and SU- specific monoclonal antibodies strongly support the involvement of the V3 loop of SU in the FIV-CXCR4 interaction.
Therefore, studies performed in Arabidopsis [ 62] may be complemented by the analysis of a broader range of BR-deficient mutants, and inhibitors specific for BR synthesis and efficient for Arabidopsis such as BRZ.
With Rac1-specific inhibitor, dominant negative mutant Rac1 (N17Rand) and specific small interfering RNA, the effect of Rac1 on IR-induced G2/M checkpoint response and ERK1/2 activation was examined in human breast cancer cells.
They include comments on genomic, cDNA and protein sequences, genetic maps, phylogeny, function, available mutants and tissue-specific gene expression based on a boutique P450 gene microarray.
We have previously shown that Tyro3 mouse mutants, Gas6 mouse mutants, and retina-specific Pros1 mouse mutants all have a normal number of PRs at this time (Prasad et al., 2006; Burstyn-Cohen et al., 2012); but that Gas6/Pros1 double mutants display PR death and retinal degeneration that fully phenocopies the degeneration of the Mertk mutants (Burstyn-Cohen et al., 2012).
It provides a rich resource of mutants and tissue-specific transgenic reporter lines, complementing other large-scale screens to facilitate the identification and functional study of known as well as novel genes and transcripts.
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