Sentence examples for mutants and altered from inspiring English sources

In conclusion, the data demonstrate a mechanistic link between Rab7 Cmutantstands alteredered TrkA and Erk1/2 signaling from endosomes.

The hypothesis of the work was that the combination of working with defined mutants and altering CO2 availability for modulation of photosynthesis allows addressing the question of how selected nuclear and plastidic genes are regulated in Arabidopsis in response to redox, metabolite and energy signals.

Among the possible explanations is that the LL2 cell line is known to have mutant p53[36], and altered p53 expression reduces sensitivity to PARPi[37].

Our study on GIST-derived PDGFRα mutants suggests that mislocalisation and altered signalling are general characteristics of constitutively active PDGFRα proteins.

To date, several mutants with defective conidiogenesis and altered conidial morphology, including smo, con1, con2, con4, con7, acr1, chm1, and com1, have been identified by chemical or insertional mutagenesis [ 5- 9].

These data indicate comparable, wild-type-like channel function for the mutants RyR2-G1885E, RyR2-G1886S, and RyR2-G1886D alteredered channel properties for the double mutant RyR2-G1885E/G1886S.

Evidence suggest that luxS mutants have both altered phenotypes and altered gene expression, however some of these changes are clearly associated with altered metabolism and the role of AI-2 mediated quorum sensing in this species remains uncertain [45], [46].

Germline ablation also significantly increases the lifespan of insulin-signaling mutants (Hsin & Kenyon, 1999) and altered signaling from the germline to the intestine is responsible for the long lifespan of double mutants between daf-2 and the intestinal di- and tripeptide transporter pept-1 (Spanier et al., 2010).

Rather, in lama1UW1 mutants, loss of epithelial polarity and altered adhesion lead to defective tissue architecture and formation of a disorganized retina.

Here, for the first time, we explored MCFA content in mutants with defective lipid droplets and altered lipid metabolism.

4-NQO has been used in many mutagenic screens since being reported as a good mutagen for producing both loss-of-function and altered function mutants in A. nidulans (Bal et al. 1977).